Ontology highlight
ABSTRACT:
SUBMITTER: Ratzon E
PROVIDER: S-EPMC6641755 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Ratzon Einav E Bloch Itai I Nicola Meshel M Cohen Elad E Ruimi Nili N Dotan Nesly N Landau Meytal M Gal Maayan M
ACS omega 20170809 8
Protein kinases are fundamental within almost all cellular signal transduction networks. Among these, Bruton's tyrosine kinase (Btk), which belongs to the Tec family of proteins, plays an imperative part in B-cell signaling. Owing to its role, Btk has been established as an important therapeutic target for a vast range of disorders related to B-cell development and function, such as the X-linked agammaglobulinemia, various B-cell malignancies, inflammation, and autoimmune diseases. Herein, using ...[more]