Dataset Information

The prognostic values of neutrophil to lymphocyte ratio for outcomes in chronic obstructive pulmonary disease.

ABSTRACT:

Objective

Neutrophil to lymphocyte ratio (NLR) is considered as an inflammatory biomarker for clinical outcomes in patients with chronic obstructive pulmonary disease (COPD). We aimed to conduct a meta-analysis to evaluate the prognostic values of NLR for the exacerbation and mortality in patients with COPD.

Methods

We searched the database of Cochrane Central Register of Controlled Trials, EMBASE, and PubMed, before September 2017. The eligible studies were retrieved by 2 authors independently following the criteria. The pooled odds ratios (ORs) of included studies were used to evaluate the prognostic values of NLR. Subgroup analyses were conducted to make the results more accurate.

Results

Nine studies with 5140 patients were enrolled in this analysis. The high NLR was associated with higher risk of exacerbation (OR: 3.81, 95% confidence interval [CI]: 1.20-12.13, P?=?.02) and mortality (OR: 2.60, 95% CI: 1.48-4.57, P?70 years (OR: 2.16, 95% CI: 1.17-3.98, P?=?.01) but not in patients <70 years (OR: 4.08, 95% CI: 0.91-18.24, P?=?.07), and had a higher predictive ability in Asian group (OR: 3.64, 95% CI: 1.87-7.08, P?ConclusionsThe NLR may be an independent predictor for incidence of exacerbation in patients with COPD. In addition, high NLR may be associated with higher mortality in patients with COPD, especially for Asian and the patients with higher mean NLR.

SUBMITTER: Ye Z

PROVIDER: S-EPMC6641779 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Publications

The prognostic values of neutrophil to lymphocyte ratio for outcomes in chronic obstructive pulmonary disease.

Ye Zengpanpan Z Ai Xiaolin X Liao Zenglin Z You Chao C Cheng Yongzhong Y

Medicine 20190701 28

<h4>Objective</h4>Neutrophil to lymphocyte ratio (NLR) is considered as an inflammatory biomarker for clinical outcomes in patients with chronic obstructive pulmonary disease (COPD). We aimed to conduct a meta-analysis to evaluate the prognostic values of NLR for the exacerbation and mortality in patients with COPD.<h4>Methods</h4>We searched the database of Cochrane Central Register of Controlled Trials, EMBASE, and PubMed, before September 2017. The eligible studies were retrieved by 2 authors ...[more]

PMID: 31305434

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Project description:BackgroundChronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and progressive decline in pulmonary function. Neutrophil-to-lymphocyte ratio (NLR), YKL-40 and calprotectin are biomarkers of inflammation and predict mortality in patients with different inflammatory diseases. We aimed to investigate the correlation between levels of these three biomarkers and neutrophil granulocyte and lymphocyte count in patients with moderate to very severe COPD stratified by use of systemic glucocorticoids. Furthermore, we studied the ability of these biomarkers to predict all-cause mortality.Methods386 patients with moderate to very severe COPD were followed prospectively for 10 years. Patients were divided into two groups according to systemic glucocorticoid use at baseline. Correlations between biomarkers were assessed by Spearman's Rho, and mortality was evaluated in uni- and multivariate Cox regression analyses with hazard ratios (HR) and 95% confidence intervals (CI).ResultsPlasma calprotectin was positively correlated with neutrophil granulocyte count and NLR. No significant association was found between plasma YKL-40 and the cellular biomarkers, irrespective of glucocorticoid treatment. In the group not treated with systemic glucocorticoids, plasma calprotectin [HR 1.002 (95% CI 1.000 - 1.004)], NLR [HR 1.090 (1.036 - 1.148)] and lymphocyte count [HR 0.667 (0.522 - 0.851)] were significantly associated with higher mortality. In the group treated with systemic glucocorticoids, higher plasma YKL-40 was significantly associated with mortality in univariate Cox regression analysis [HR 1.006 (1.003 - 1.008)].ConclusionsCalprotectin was related to neutrophil granulocyte count and NLR in patients with moderate to very severe COPD in stable phase and not in treatment with systemic glucocorticoids. Lymphopenia, higher plasma calprotectin and higher NLR were independent predictors of increased all-cause mortality in this group. Our data also suggests that treatment with systemic glucocorticoids has a significant impact on the ability of inflammatory biomarkers to predict all-cause mortality.Trial registrationClinicalTrials.gov NCT00132860.

Dataset Information

The prognostic values of neutrophil to lymphocyte ratio for outcomes in chronic obstructive pulmonary disease.

Objective

Methods

Results

Publications

The prognostic values of neutrophil to lymphocyte ratio for outcomes in chronic obstructive pulmonary disease.

Similar Datasets

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