Stability Study of Hypervalent Tellurium Compounds in Aqueous Solutions.

ABSTRACT: Hypervalent tellurium compounds (telluranes) are promising therapeutical agents with negligible toxicities for some diseases in animal models. The C-Te bond of organotellurium compounds is commonly considered unstable, disfavoring their applicability in biological studies. In this study, the stability of a set of telluranes composed of an inorganic derivative and noncharged and charged organic derivatives was monitored in aqueous media with 1H, 13C, and 125Te NMR spectroscopy and high-resolution mass spectrometry. Organic telluranes were found to be remarkably resistant and stable to hydrolysis, whereas the inorganic tellurane AS101 is totally converted to the hydrolysis product, trichlorooxytellurate, [TeOCl 3 ]-, which was also observed in the hydrolysis of TeCl 4 . The noteworthy stability of organotelluranes in aqueous media makes them prone to further structure-activity relationship studies and to be considered for broad biological investigations.

SUBMITTER: Princival CR 

PROVIDER: S-EPMC6641895 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature