Programmable dynamic steady states in ATP-driven nonequilibrium DNA systems.

ABSTRACT: Inspired by the dynamics of the dissipative self-assembly of microtubules, chemically fueled synthetic systems with transient lifetimes are emerging for nonequilibrium materials design. However, realizing programmable or even adaptive structural dynamics has proven challenging because it requires synchronization of energy uptake and dissipation events within true steady states, which remains difficult to orthogonally control in supramolecular systems. Here, we demonstrate full synchronization of both events by ATP-fueled activation and dynamization of covalent DNA bonds via an enzymatic reaction network of concurrent ligation and cleavage. Critically, the average bond ratio and the frequency of bond exchange are imprinted into the energy dissipation kinetics of the network and tunable thro

SUBMITTER: Heinen L 

PROVIDER: S-EPMC6641946 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature