Ontology highlight
ABSTRACT:
SUBMITTER: Chung CY
PROVIDER: S-EPMC6641988 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Chung Clive Yik-Sham CY Shin Hijai R HR Berdan Charles A CA Ford Breanna B Ward Carl C CC Olzmann James A JA Zoncu Roberto R Nomura Daniel K DK
Nature chemical biology 20190708 8
Autophagy is a lysosomal degradation pathway that eliminates aggregated proteins and damaged organelles to maintain cellular homeostasis. A major route for activating autophagy involves inhibition of the mTORC1 kinase, but current mTORC1-targeting compounds do not allow complete and selective mTORC1 blockade. Here, we have coupled screening of a covalent ligand library with activity-based protein profiling to discover EN6, a small-molecule in vivo activator of autophagy that covalently targets c ...[more]