Ontology highlight
ABSTRACT:
SUBMITTER: Bergsland N
PROVIDER: S-EPMC6642003 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Movement disorders : official journal of the Movement Disorder Society 20190610 7
<h4>Background</h4>Parkinson's disease (PD) is characterized in part by the progressive accumulation of iron within the substantia nigra (SN); however, its spatial and temporal dynamics remain relatively poorly understood.<h4>Objectives</h4>The objective of this study was to investigate spatial patterns and temporal evolution of SN iron accumulation in PD.<h4>Methods</h4>A total of 18 PD patients (mean disease duration = 6.2 years) receiving dopaminergic therapy and 16 healthy controls were scan ...[more]