Ontology highlight
ABSTRACT:
SUBMITTER: Asimit JL
PROVIDER: S-EPMC6642100 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nature communications 20190719 1
Thousands of genetic variants are associated with human disease risk, but linkage disequilibrium (LD) hinders fine-mapping the causal variants. Both lack of power, and joint tagging of two or more distinct causal variants by a single non-causal SNP, lead to inaccuracies in fine-mapping, with stochastic search more robust than stepwise. We develop a computationally efficient multinomial fine-mapping (MFM) approach that borrows information between diseases in a Bayesian framework. We show that MFM ...[more]