Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh RP
PROVIDER: S-EPMC6642133 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Ghosh Rajarshi P RP Ghosh Rajarshi P RP Shi Quanming Q Yang Linfeng L Reddick Michael P MP Nikitina Tatiana T Zhurkin Victor B VB Fordyce Polly P Stasevich Timothy J TJ Chang Howard Y HY Greenleaf William J WJ Liphardt Jan T JT
Nature communications 20190719 1
The Satb1 genome organizer regulates multiple cellular and developmental processes. It is not yet clear how Satb1 selects different sets of targets throughout the genome. Here we have used live-cell single molecule imaging and deep sequencing to assess determinants of Satb1 binding-site selectivity. We have found that Satb1 preferentially targets nucleosome-dense regions and can directly bind consensus motifs within nucleosomes. Some genomic regions harbor multiple, regularly spaced Satb1 bindin ...[more]