Ontology highlight
ABSTRACT:
SUBMITTER: Stewart TA
PROVIDER: S-EPMC6642197 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Stewart Thomas A TA Liang Cong C Cotney Justin L JL Noonan James P JP Sanger Thomas J TJ Wagner Günter P GP
Nature communications 20190719 1
In crown group tetrapods, individual digits are homologized in relation to a pentadactyl ground plan. However, testing hypotheses of digit homology is challenging because it is unclear whether digits represent distinct and conserved gene regulatory states. Here we show dramatic evolutionary dynamism in the gene expression profiles of digits, challenging the notion that five digits have conserved developmental identities across amniotes. Transcriptomics shows diversity in the patterns of gene exp ...[more]