Two types of functionally distinct Ca2+ stores in hippocampal neurons.
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ABSTRACT:
SUBMITTER: Chen-Engerer HJ
PROVIDER: S-EPMC6642203 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Two types of functionally distinct Ca<sup>2+</sup> stores in hippocampal neurons.
Chen-Engerer Hsing-Jung HJ Hartmann Jana J Karl Rosa Maria RM Yang Jun J Feske Stefan S Konnerth Arthur A
Nature communications 20190719 1
It is widely assumed that inositol trisphosphate (IP<sub>3</sub>) and ryanodine (Ry) receptors share the same Ca<sup>2+</sup> pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP<sub>3</sub>- and Ry-receptors are associated with two functionally distinct intracellular Ca<sup>2+</sup> stores, respectively. While the IP<sub>3</sub>-sensitive Ca<sup>2+</sup> store refilling requires Orai2 channels, Ry-sensitive Ca<sup>2+</sup> store refilling involves v ...[more]
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