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Two types of functionally distinct Ca2+ stores in hippocampal neurons.


ABSTRACT: It is widely assumed that inositol trisphosphate (IP3) and ryanodine (Ry) receptors share the same Ca2+ pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP3- and Ry-receptors are associated with two functionally distinct intracellular Ca2+ stores, respectively. While the IP3-sensitive Ca2+ store refilling requires Orai2 channels, Ry-sensitive Ca2+ store refilling involves voltage-gated Ca2+ channels (VGCCs). Our findings have direct implications for the understanding of function and plasticity in these central mammalian neurons.

SUBMITTER: Chen-Engerer HJ 

PROVIDER: S-EPMC6642203 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Two types of functionally distinct Ca<sup>2+</sup> stores in hippocampal neurons.

Chen-Engerer Hsing-Jung HJ   Hartmann Jana J   Karl Rosa Maria RM   Yang Jun J   Feske Stefan S   Konnerth Arthur A  

Nature communications 20190719 1


It is widely assumed that inositol trisphosphate (IP<sub>3</sub>) and ryanodine (Ry) receptors share the same Ca<sup>2+</sup> pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP<sub>3</sub>- and Ry-receptors are associated with two functionally distinct intracellular Ca<sup>2+</sup> stores, respectively. While the IP<sub>3</sub>-sensitive Ca<sup>2+</sup> store refilling requires Orai2 channels, Ry-sensitive Ca<sup>2+</sup> store refilling involves v  ...[more]

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