Dataset Information

Long noncoding RNA EMS connects c-Myc to cell cycle control and tumorigenesis.

ABSTRACT: Deregulated expression of c-Myc is an important molecular hallmark of cancer. The oncogenic function of c-Myc has been largely attributed to its intrinsic nature as a master transcription factor. Here, we report the long noncoding RNA (lncRNA) E2F1 messenger RNA (mRNA) stabilizing factor (EMS) as a direct c-Myc transcriptional target. EMS functions as an oncogenic molecule by promoting G1/S cell cycle progression. Mechanistically, EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression. Furthermore, EMS is able to connect c-Myc to cell cycle control and tumorigenesis via modulating E2F1 mRNA stability. Together, these findings reveal a previously unappreciated mechanism through which c-Myc induces E2F1 expression and also implicate EMS as an important player in the regulation of c-Myc function.

SUBMITTER: Wang C

PROVIDER: S-EPMC6642410 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Long noncoding RNA EMS connects c-Myc to cell cycle control and tumorigenesis.

Wang Chenfeng C Yang Yang Y Zhang Guang G Li Jingxin J Wu Xianning X Ma Xiaoling X Shan Ge G Mei Yide Y

Proceedings of the National Academy of Sciences of the United States of America 20190701 29

Deregulated expression of c-Myc is an important molecular hallmark of cancer. The oncogenic function of c-Myc has been largely attributed to its intrinsic nature as a master transcription factor. Here, we report the long noncoding RNA (lncRNA) E2F1 messenger RNA (mRNA) stabilizing factor (EMS) as a direct c-Myc transcriptional target. EMS functions as an oncogenic molecule by promoting G1/S cell cycle progression. Mechanistically, EMS cooperates with the RNA binding protein RALY to stabilize E2F ...[more]

PMID: 31262817

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Dataset Information

Long noncoding RNA EMS connects c-Myc to cell cycle control and tumorigenesis.

Publications

Long noncoding RNA EMS connects c-Myc to cell cycle control and tumorigenesis.

Similar Datasets

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