Overexpression of Pin1 and rho signaling partners correlates with metastatic behavior and poor recurrence-free survival of hepatocellular carcinoma patients.
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ABSTRACT:
SUBMITTER: Ng L
PROVIDER: S-EPMC6642482 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Overexpression of Pin1 and rho signaling partners correlates with metastatic behavior and poor recurrence-free survival of hepatocellular carcinoma patients.
Ng Lui L Kwan Virginia V Chow Ariel A Yau Thomas Chung-Cheung TC Poon Ronnie Tung-Ping RT Pang Roberta R Law Wai-Lun WL
BMC cancer 20190719 1
<h4>Background</h4>Identification of molecular markers for early detection or prediction of metastasis is crucial for both management of HCC patient postoperative treatment and identify new therapeutic targets to inhibit HCC progression and metastasis. In the current study, we investigated the clinical correlation between Pin1, RhoA and RhoC and their association with HCC metastasis.<h4>Methods</h4>Using a randomized study design of primary HCC samples from 139 patients, we determined messenger ...[more]
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