Absence of an embryonic stem cell DNA methylation signature in human cancer.
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ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC6642562 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Absence of an embryonic stem cell DNA methylation signature in human cancer.
Zhang Ze Z Wiencke John K JK Koestler Devin C DC Salas Lucas A LA Christensen Brock C BC Kelsey Karl T KT
BMC cancer 20190719 1
<h4>Background</h4>Differentiated cells that arise from stem cells in early development contain DNA methylation features that provide a memory trace of their fetal cell origin (FCO). The FCO signature was developed to estimate the proportion of cells in a mixture of cell types that are of fetal origin and are reminiscent of embryonic stem cell lineage. Here we implemented the FCO signature estimation method to compare the fraction of cells with the FCO signature in tumor tissues and their corres ...[more]
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