Ontology highlight
ABSTRACT:
SUBMITTER: Fang Y
PROVIDER: S-EPMC6642675 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Fang Yong Y McGrail Daniel J DJ Sun Chaoyang C Labrie Marilyne M Chen Xiaohua X Zhang Dong D Ju Zhenlin Z Vellano Christopher P CP Lu Yiling Y Li Yongsheng Y Jeong Kang Jin KJ Ding Zhiyong Z Liang Jiyong J Wang Steven W SW Dai Hui H Lee Sanghoon S Sahni Nidhi N Mercado-Uribe Imelda I Kim Tae-Beom TB Chen Ken K Lin Shiaw-Yih SY Peng Guang G Westin Shannon N SN Liu Jinsong J O'Connor Mark J MJ Yap Timothy A TA Mills Gordon B GB
Cancer cell 20190601 6
We demonstrate that concurrent administration of poly(ADP-ribose) polymerase (PARP) and WEE1 inhibitors is effective in inhibiting tumor growth but poorly tolerated. Concurrent treatment with PARP and WEE1 inhibitors induces replication stress, DNA damage, and abrogates the G<sub>2</sub> DNA damage checkpoint in both normal and malignant cells. Following cessation of monotherapy with PARP or WEE1 inhibitors, effects of these inhibitors persist suggesting that sequential administration of PARP an ...[more]