Ontology highlight
ABSTRACT:
SUBMITTER: Morou A
PROVIDER: S-EPMC6642691 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Nature immunology 20190715 8
Dysfunction of virus-specific CD4<sup>+</sup> T cells in chronic human infections is poorly understood. We performed genome-wide transcriptional analyses and functional assays of CD4<sup>+</sup> T cells specific for human immunodeficiency virus (HIV) from HIV-infected people before and after initiation of antiretroviral therapy (ART). A follicular helper T cell (T<sub>FH</sub> cell)-like profile characterized HIV-specific CD4<sup>+</sup> T cells in viremic infection. HIV-specific CD4<sup>+</sup> ...[more]