Ontology highlight
ABSTRACT:
SUBMITTER: Ayalon I
PROVIDER: S-EPMC6643168 | biostudies-literature | 2019 Jan-Dec
REPOSITORIES: biostudies-literature
Journal of investigative medicine high impact case reports 20190101
High-dose methotrexate is used to treat a range of adult and childhood cancers including osteosarcoma. Significant neurotoxicity is reported in 1% to 4.5% of patients treated with high-dose methotrexate and can present in a wide variety of symptoms. We present a case of a 14-year-old boy with a recent diagnosis of osteosarcoma who presented to the emergency department with status epilepticus, altered mental status, and very high fever secondary to methotrexate neurotoxicity. We review current li ...[more]