Ontology highlight
ABSTRACT:
SUBMITTER: AlSiraj Y
PROVIDER: S-EPMC6643208 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
AlSiraj Yasir Y Chen Xuqi X Thatcher Sean E SE Temel Ryan E RE Cai Lei L Blalock Eric E Katz Wendy W Ali Heba M HM Petriello Michael M Deng Pan P Morris Andrew J AJ Wang Xuping X Lusis Aldons J AJ Arnold Arthur P AP Reue Karen K Thompson Katherine K Tso Patrick P Cassis Lisa A LA
Nature communications 20190614 1
Men and women differ in circulating lipids and coronary artery disease (CAD). While sex hormones such as estrogens decrease CAD risk, hormone replacement therapy increases risk. Biological sex is determined by sex hormones and chromosomes, but effects of sex chromosomes on circulating lipids and atherosclerosis are unknown. Here, we use mouse models to separate effects of sex chromosomes and hormones on atherosclerosis, circulating lipids and intestinal fat metabolism. We assess atherosclerosis ...[more]