Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC6643211 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Li Xiaocong X Hao Fei F Hu Xiao X Wang Hui H Dai Bai B Wang Xiao X Liang Hao H Cang Ming M Liu Dongjun D
International journal of biological sciences 20190703 8
The cashmere goat breed is known to provide excellent quality cashmere. Here, we attempted to breed high-yielding cashmere goats by specifically inserting the Tβ4 gene into the goat CCR5 locus and provided an animal model for future research. We successfully obtained Tβ4 knock-in goat without any screening and fluorescent markers using CRISPR/Cas9 technology. A series of experiments were performed to examine physical conditions and characteristics of the Tβ4 knock-in goat. The goat exhibited an ...[more]