Adrenoceptor-stimulated inflammatory response in stress-induced serum amyloid A synthesis.

ABSTRACT:

Rationale

Stressful life events are suggested to contribute to the development of various pathologies, such as cardiovascular disorders, whose etiopathogenesis is highly associated with elevated levels of serum amyloid A (SAA) proteins. SAA synthesis in the liver is regulated by a complex network of cytokines acting independently or in concert with various hormones/stimulants including the stress-activated sympathetic nervous system.

Objective

This study aims to investigate the underlying mechanisms that regulate the stress-induced hepatic synthesis of SAA, with particular focus on adrenoceptors (AR), major components of the sympathoadrenal response to stress.

Methods and results

We demonstrated that repeated stress elevates IL-1β, IL-6, and TNFα serum levels in mice,

SUBMITTER: Konstandi M 

PROVIDER: S-EPMC6643287 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature