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Transition Metal- and Oxidant-Free Base-Mediated Selenation of Bicyclic Arenes at Room Temperature.

ABSTRACT: Bicyclic arenyl selenides are of much importance because of their pharmaceutical applications. A simple method for their synthesis has been developed by a reaction of 2-naphthol and styrenyl selenocyanate/diaryl diselenide in the presence of a base at room temperature. The selenation occurs exclusively at the 1-position of 2-naphthol unit. The reactions are relatively fast (2-4 h) and high yielding. A library of substituted naphthyl styrenyl and naphthyl aryl selenides are obtained by this procedure.

SUBMITTER: Ghosh T

PROVIDER: S-EPMC6643595 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Transition Metal- and Oxidant-Free Base-Mediated Selenation of Bicyclic Arenes at Room Temperature.

Ghosh Tubai T Mukherjee Nilanjana N Ranu Brindaban C BC

ACS omega 20181217 12

Bicyclic arenyl selenides are of much importance because of their pharmaceutical applications. A simple method for their synthesis has been developed by a reaction of 2-naphthol and styrenyl selenocyanate/diaryl diselenide in the presence of a base at room temperature. The selenation occurs exclusively at the 1-position of 2-naphthol unit. The reactions are relatively fast (2-4 h) and high yielding. A library of substituted naphthyl styrenyl and naphthyl aryl selenides are obtained by this proce ...[more]

PMID: 31458358

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