Photo-controlled delivery of a potent analogue of doxorubicin.
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ABSTRACT:
SUBMITTER: Dupart PS
PROVIDER: S-EPMC6643956 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Photo-controlled delivery of a potent analogue of doxorubicin.
Dupart Patrick S PS Mitra Koushambi K Lyons Charles E CE Hartman Matthew C T MCT
Chemical communications (Cambridge, England) 20190501 39
Highly cytotoxic agents have found an important niche in targeted anticancer therapy. Here we develop a new light release strategy for the targeting of one of these agents, 2-pyrrolinodoxorubicin, showing dramatic enhancements in toxicity with light and single digit nM potency. ...[more]
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