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Cyanide-Free Ce(III)-Catalyzed Highly Efficient Synthesis of ?-Iminonitriles from 2-Aminopyridines and Nitroalkenes via Intermolecular Dehydration Reaction.

ABSTRACT: A direct and rapid method for the synthesis of ?-iminonitriles achieved good to excellent yields. A novel intermolecular dehydration reaction between 2-aminopyridines and nitroalkenes is reported via a rare-earth-metal catalyst. The merits of this transformation include cyanide-free protocol, short reaction time, simple operation, water as the only byproduct, commercially available reagents, good functional group tolerance, etc. Moreover, nitroalkenes are demonstrated as a new "CN" source in this transformation.

SUBMITTER: Chen Z

PROVIDER: S-EPMC6644690 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Cyanide-Free Ce(III)-Catalyzed Highly Efficient Synthesis of α-Iminonitriles from 2-Aminopyridines and Nitroalkenes via Intermolecular Dehydration Reaction.

Chen Zhengwang Z Liang Pei P Zheng Jing J Zhou Zhonggao Z Wen Xiaowei X Liu Tanggao T Ye Min M

ACS omega 20181003 10

A direct and rapid method for the synthesis of α-iminonitriles achieved good to excellent yields. A novel intermolecular dehydration reaction between 2-aminopyridines and nitroalkenes is reported via a rare-earth-metal catalyst. The merits of this transformation include cyanide-free protocol, short reaction time, simple operation, water as the only byproduct, commercially available reagents, good functional group tolerance, etc. Moreover, nitroalkenes are demonstrated as a new "CN" source in thi ...[more]

PMID: 31457985

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