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The Genome Sequence of the Anthelmintic-Susceptible New Zealand Haemonchus contortus.


ABSTRACT: Internal parasitic nematodes are a global animal health issue causing drastic losses in livestock. Here, we report a H. contortus representative draft genome to serve as a genetic resource to the scientific community and support future experimental research of molecular mechanisms in related parasites. A de novo hybrid assembly was generated from PCR-free whole genome sequence data, resulting in a chromosome-level assembly that is 465 Mb in size encoding 22,341 genes. The genome sequence presented here is consistent with the genome architecture of the existing Haemonchus species and is a valuable resource for future studies regarding population genetic structures of parasitic nematodes. Additionally, comparative pan-genomics with other species of economically important parasitic nematodes have revealed highly open genomes and strong collinearities within the phylum Nematoda.

SUBMITTER: Palevich N 

PROVIDER: S-EPMC6644846 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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The Genome Sequence of the Anthelmintic-Susceptible New Zealand Haemonchus contortus.

Palevich Nikola N   Maclean Paul H PH   Baten Abdul A   Scott Richard W RW   Leathwick David M DM  

Genome biology and evolution 20190701 7


Internal parasitic nematodes are a global animal health issue causing drastic losses in livestock. Here, we report a H. contortus representative draft genome to serve as a genetic resource to the scientific community and support future experimental research of molecular mechanisms in related parasites. A de novo hybrid assembly was generated from PCR-free whole genome sequence data, resulting in a chromosome-level assembly that is 465 Mb in size encoding 22,341 genes. The genome sequence present  ...[more]

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