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Bulk and Surface-Stabilized Structures of Paracetamol Revisited by Raman Confocal Microscopy.

ABSTRACT: We revisit the polymorphism of paracetamol by means of a micro-Raman technique, which has proved to be a powerful tool for structure recognition. Distinct lattice phonon spectra clearly identified the pure phases. Confocality enabled us to detect phase mixing between form II and either I or III on a micrometric scale in the same crystallite. Following the most recent findings on surface-mediated structures, we also investigated spin-coated films grown on glass, gold, and polystyrene substrates, confirming the selectivity of these surfaces for the metastable form III, which shows an unprecedented stability over a time span of several months. A mechanism of its transformation to phase II, via a partially ordered intermediate state, is suggested by polarized Raman measurements.

SUBMITTER: Rivalta A

PROVIDER: S-EPMC6645084 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Bulk and Surface-Stabilized Structures of Paracetamol Revisited by Raman Confocal Microscopy.

Rivalta Arianna A Salzillo Tommaso T Venuti Elisabetta E Della Valle Raffaele G RG Sokolovič Barbara B Werzer Oliver O Brillante Aldo A

ACS omega 20180820 8

We revisit the polymorphism of paracetamol by means of a micro-Raman technique, which has proved to be a powerful tool for structure recognition. Distinct lattice phonon spectra clearly identified the pure phases. Confocality enabled us to detect phase mixing between form II and either I or III on a micrometric scale in the same crystallite. Following the most recent findings on surface-mediated structures, we also investigated spin-coated films grown on glass, gold, and polystyrene substrates, ...[more]

PMID: 31459088

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