Ontology highlight
ABSTRACT:
SUBMITTER: Szatylowicz H
PROVIDER: S-EPMC6645133 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Szatylowicz Halina H Jezuita Anna A Siodła Tomasz T Varaksin Konstantin S KS Domanski Mateusz A MA Ejsmont Krzysztof K Krygowski Tadeusz M TM
ACS omega 20171026 10
An application of a charge of the substituent active region concept to 1-Y,4-X-disubstituted derivatives of bicyclo[2.2.2]octane (BCO) [where Y = NO<sub>2</sub>, COOH, OH, and NH<sub>2</sub> and X = NMe<sub>2</sub>, NH<sub>2</sub>, OH, OMe, Me, H, F, Cl, CF<sub>3</sub>, CN, CHO, COMe, CONH<sub>2</sub>, COOH, NO<sub>2</sub>, and NO] provides a quantitative information on the inductive component of the substituent effect (SE). It is shown that the effect is highly additive but dependent on the kin ...[more]