Ontology highlight
ABSTRACT:
SUBMITTER: Ansaldo E
PROVIDER: S-EPMC6645389 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Ansaldo Eduard E Slayden Leianna C LC Ching Krystal L KL Koch Meghan A MA Wolf Natalie K NK Plichta Damian R DR Brown Eric M EM Graham Daniel B DB Xavier Ramnik J RJ Moon James J JJ Moon James J JJ Barton Gregory M GM
Science (New York, N.Y.) 20190601 6446
Intestinal adaptive immune responses influence host health, yet only a few intestinal bacteria species that induce cognate adaptive immune responses during homeostasis have been identified. Here, we show that <i>Akkermansia muciniphila</i>, an intestinal bacterium associated with systemic effects on host metabolism and PD-1 checkpoint immunotherapy, induces immunoglobulin G1 (IgG1) antibodies and antigen-specific T cell responses in mice. Unlike previously characterized mucosal responses, T cell ...[more]