Dataset Information

Deficiency of Adipocyte IKK? Affects Atherosclerotic Plaque Vulnerability in Obese LDLR Deficient Mice.

ABSTRACT: Background Obesity-associated chronic inflammation has been known to contribute to atherosclerosis development, but the underlying mechanisms remain elusive. Recent studies have revealed novel functions of IKK ? (inhibitor of NF -?B [nuclear factor ?B] kinase ?), a key coordinator of inflammation through activation of NF -?B, in atherosclerosis and adipose tissue development. However, it is not clear whether IKK ? signaling in adipocytes can also affect atherogenesis. This study aims to investigate the impact of adipocyte IKK ? expression on atherosclerosis development in lean and obese LDLR (low-density lipoprotein receptor)-deficient ( LDLR ^-/-) mice. Methods and Results To define the role of adipocyte IKK ? in atherogenesis, we generated adipocyte-specific IKK ?-deficient LDLR ^-/- ( IKK ?^?Ad LDLR ^-/-) mice. Targeted deletion of IKK ? in adipocytes did not affect adiposity and atherosclerosis in lean LDLR ^-/- mice when fed a low-fat diet. In response to high-fat feeding, however, IKK ?^?Ad LDLR ^-/- mice had defective adipose remodeling and increased adipose tissue and systemic inflammation. Deficiency of adipocyte IKK ? did not affect atherosclerotic lesion sizes but resulted in enhanced lesional inflammation and increased plaque vulnerability in obese IKK ?^?Ad LDLR ^-/- mice. Conclusions These data demonstrate that adipocyte IKK ? signaling affects the evolution of atherosclerosis plaque vulnerability in obese LDLR ^-/- mice. This study suggests that the functions of IKK ? signaling in atherogenesis are complex, and IKK ? in different cell types or tissues may have different effects on atherosclerosis development.

SUBMITTER: Lu W

PROVIDER: S-EPMC6645619 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Deficiency of Adipocyte IKKβ Affects Atherosclerotic Plaque Vulnerability in Obese LDLR Deficient Mice.

Lu Weiwei W Park Se-Hyung SH Meng Zhaojie Z Wang Fang F Zhou Changcheng C

Journal of the American Heart Association 20190615 12

Background Obesity-associated chronic inflammation has been known to contribute to atherosclerosis development, but the underlying mechanisms remain elusive. Recent studies have revealed novel functions of IKK β (inhibitor of NF -κB [nuclear factor κB] kinase β), a key coordinator of inflammation through activation of NF -κB, in atherosclerosis and adipose tissue development. However, it is not clear whether IKK β signaling in adipocytes can also affect atherogenesis. This study aims to investig ...[more]

PMID: 31203708

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Dataset Information

Deficiency of Adipocyte IKK? Affects Atherosclerotic Plaque Vulnerability in Obese LDLR Deficient Mice.

Publications

Deficiency of Adipocyte IKKβ Affects Atherosclerotic Plaque Vulnerability in Obese LDLR Deficient Mice.

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