RNA Sequencing Reveals the Activation of Wnt Signaling in Low Flow Rate Brain Arteriovenous Malformations.

ABSTRACT: Background The blood flow rate of brain arteriovenous malformations ( bAVM s) is an important clinical characteristic closely associated with the hemorrhage risk and radiosurgery obliteration rate of bAVM s. However, the underlying molecular properties remain unclear. To identify potential key molecules, signaling pathways, and vascular cell types involved, we compared gene expression profiles between bAVM s with high flow rates and low flow rates ( LFR ) and validated the functions of selected key molecules in vitro. Methods and Results We performed RNA -sequencing analysis on 51 samples, including 14 high flow rate bAVM s and 37 LFR bAVM s. Functional pathway analysis was performed to identify potential signals influencing the flow rate phenotype of bAVM s. Candidate genes were investiga

SUBMITTER: Huo R 

PROVIDER: S-EPMC6645621 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature