Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC6645658 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Li Xin X He Wei W Chen Yang Y Yang Guimei G Wan Hong H Zhang Lei L Hu Qiyue Q Feng Jun J Zhang Zhigao Z He Feng F Bai Chang C Zhang Lianshan L You Li L Tao Weikang W
ACS omega 20171228 12
Recently, targeting the G protein-biased signaling has emerged as an attractive therapeutic strategy for treating severe acute pain with the potential to reduce the side effect of the traditional opioid drug. Herein, we describe the discovery of a highly potent G protein-biased μ-opioid receptor (MOR) agonist, SHR9352. This novel molecule exhibited excellent MOR activity and limited β-arrestin recruitment, as well as a high selectivity over κ-opioid receptor and δ-opioid receptor demonstrated ro ...[more]