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Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype.

ABSTRACT: INTRODUCTION:We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer's disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration. METHODS:We performed multistate modeling in a combined sample of 6 cohorts (n = 3268) with death as the end stage and estimated the preclinical, prodromal, and dementia stage duration. RESULTS:The overall AD duration varied between 24 years (age 60) and 15 years (age 80). For individuals presenting with preclinical AD, age 70, the estimated preclinical AD duration was 10 years, prodromal AD 4 years, and dementia 6 years. Male sex, clinical setting, APOE ?4 allele carriership, and abnormal cerebrospinal fluid tau were associated with a shorter duration, and these effects depended on disease stage. DISCUSSION:Estimates of AD disease duration become more accurate if age, sex, setting, APOE, and cerebrospinal fluid tau are taken into account. This will be relevant for clinical practice and trial design.

SUBMITTER: Vermunt L

PROVIDER: S-EPMC6646097 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype.

Vermunt Lisa L Sikkes Sietske A M SAM van den Hout Ardo A Handels Ron R Bos Isabelle I van der Flier Wiesje M WM Kern Silke S Ousset Pierre-Jean PJ Maruff Paul P Skoog Ingmar I Verhey Frans R J FRJ Freund-Levi Yvonne Y Tsolaki Magda M Wallin Åsa K ÅK Olde Rikkert Marcel M Soininen Hilkka H Spiru Luisa L Zetterberg Henrik H Blennow Kaj K Scheltens Philip P Muniz-Terrera Graciela G Visser Pieter Jelle PJ

Alzheimer's & dementia : the journal of the Alzheimer's Association 20190601 7

<h4>Introduction</h4>We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer's disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration.<h4>Methods</h4>We performed multistate modeling in a combined sample of 6 cohorts (n = 3268) with death as the end stage and estimated the preclinical, prodromal, and dementia stage duration.<h4>Results</h4>The overall AD duration varied betwe ...[more]

PMID: 31164314

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Dataset Information

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype.

Publications

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype.

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