Ontology highlight
ABSTRACT:
SUBMITTER: Tischfield DJ
PROVIDER: S-EPMC6646301 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20190722 1
While patient-derived xenograft (PDX) models of hepatocellular carcinoma (HCC) have been successfully generated from resected tissues, no reliable methods have been reported for the generation of PDXs from patients who are not candidates for resection and represent the vast majority of patients with HCC. Here we compare two methods for the creation of PDXs from HCC biopsies and find that implantation of whole biopsy samples without the addition of basement membrane matrix favors the formation of ...[more]