Ontology highlight
ABSTRACT:
SUBMITTER: Kim TJ
PROVIDER: S-EPMC6646315 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Kim Tae-Jin TJ Park Gayoung G Kim Jeongmin J Lim Seon Ah SA Kim Jiyoung J Im Kyungtaek K Shin Min Hwa MH Fu Yang-Xin YX Fu Yang-Xin YX Del Rio Maria-Luisa ML Rodriguez-Barbosa Jose-Ignacio JI Yee Cassian C Suh Kyung-Suk KS Kim Seong-Jin SJ Ha Sang-Jun SJ Lee Kyung-Mi KM
Nature communications 20190722 1
CD160 and BTLA both bind to herpes virus entry mediator. Although a negative regulatory function of BTLA in natural killer T (NKT) cell activation has been reported, whether CD160 is also involved is unclear. By analyzing CD160<sup>-/-</sup> mice and mixed bone marrow chimeras, we show that CD160 is not essential for NKT cell development. However, CD160<sup>-/-</sup> mice exhibit severe liver injury after in vivo challenge with α-galactosylceramide (α-GalCer). Moreover, CD160<sup>-/-</sup> mice ...[more]