Ontology highlight
ABSTRACT:
SUBMITTER: Shimura M
PROVIDER: S-EPMC6646320 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Shimura Masaru M Nozawa Naoko N Ogawa-Tominaga Minako M Fushimi Takuya T Tajika Makiko M Ichimoto Keiko K Matsunaga Ayako A Tsuruoka Tomoko T Kishita Yoshihito Y Ishii Takuya T Takahashi Kiwamu K Tanaka Tohru T Nakajima Motowo M Okazaki Yasushi Y Ohtake Akira A Murayama Kei K
Scientific reports 20190722 1
Mitochondrial respiratory chain complexes II, III, and IV and cytochrome c contain haem, which is generated by the insertion of Fe<sup>2+</sup> into protoporphyrin IX. 5-Aminolevulinic acid (ALA) combined with sodium ferrous citrate (SFC) was reported to enhance haem production, leading to respiratory complex and haem oxygenase-1 (HO-1) upregulation. Here, we investigated the effects of different concentrations of ALA and SFC alone or in combination (ALA/SFC) on fibroblasts from 8 individuals wi ...[more]