Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata.

ABSTRACT: Gastrodia elata is a famous traditional Chinese herb with medicinal and edible application. In this study, three new polybenzyls, gastropolybenzylols G-I (1-3) were isolated from the EtOAc extract of G. elata. Their structures were identified by extensive spectroscopic analyses involving HRESIMS, UV, IR, 1D and 2D NMR. Compound 1 showed agonistic effects on MT₁ and MT₂ receptors with agonistic rates of 55.91±4.84% and 165.13±5.65% at the concentration of 0.5 mM, respectively, and an EC₅₀ value of 76.24 ?M on MT₂ receptor.

SUBMITTER: Chen SY 

PROVIDER: S-EPMC6646438 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature