Ontology highlight
ABSTRACT:
SUBMITTER: Krizova A
PROVIDER: S-EPMC6647248 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Krizova Adéla A Maltan Lena L Derler Isabella I
European biophysics journal : EBJ 20190321 5
Ca<sup>2+</sup> ions represent versatile second messengers that regulate a huge diversity of processes throughout the cell's life. One prominent Ca<sup>2+</sup> entry pathway into the cell is the Ca<sup>2+</sup> release-activated Ca<sup>2+</sup> (CRAC) ion channel. It is fully reconstituted by the two molecular key players: the stromal interaction molecule (STIM1) and Orai. STIM1 is a Ca<sup>2+</sup> sensor located in the membrane of the endoplasmic reticulum, and Orai, a highly Ca<sup>2+</sup> ...[more]