Ontology highlight
ABSTRACT:
SUBMITTER: Mattaini KR
PROVIDER: S-EPMC6647269 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Mattaini Katherine R KR Sullivan Mark R MR Lau Allison N AN Fiske Brian P BP Bronson Roderick T RT Vander Heiden Matthew G MG
BMC cancer 20190722 1
<h4>Background</h4>Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas.<h4>Methods</h4>In order to study the effect of increased PHGDH expression in tissues in vivo, we generated mice harboring a PHGDH<sup>tetO</sup> allele that allows tissue-specific, doxycycline-inducible PHGDH expression, and we analyzed the phenotype of mice with a ubiquitous increase in ...[more]