Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs.
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ABSTRACT:
SUBMITTER: Barberio MD
PROVIDER: S-EPMC6647309 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs.
Barberio Matthew D MD Kasselman Lora J LJ Playford Martin P MP Epstein Samuel B SB Renna Heather A HA Goldberg Madeleine M DeLeon Joshua J Voloshyna Iryna I Barlev Ashley A Salama Michael M Ferrante Sarah C SC Nadler Evan P EP Mehta Nehal N Reiss Allison B AB Freishtat Robert J RJ
Journal of translational medicine 20190722 1
<h4>Background</h4>Macrophage cholesterol efflux capacity has been identified as a predictor for cardiovascular disease. We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage cholesterol efflux capacity.<h4>Methods</h4>We assessed an adolescent cohort (n = 93, Age, median (IQR) = 17 (3) year, Female = 71, Male = 22) throughout the BMI continuum (BMI = 45.2 (13.2) kg/m<sup>2</sup>) for: (1) cholesterol efflux capacity and lipoprotein profiles; (2) a ...[more]
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