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Catalyst-Free Approach for Hydroboration of Carboxylic Acids under Mild Conditions.

ABSTRACT: Herein, we present a facile method for deoxygenative hydroboration of a broad range of carboxylic acids under very mild conditions. The most striking feature of this attractive hydroboration is that this elusive and challenging transformation was realized without catalyst and solvent. The investigation of solvent effect showed that tetrahydrofuran was also suitable for this kind of reaction. Moreover, a successful gram-scale trial may provide a very promising toolkit for carboxylic acid reduction at a large scale.

SUBMITTER: Xu X

PROVIDER: S-EPMC6647974 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Catalyst-Free Approach for Hydroboration of Carboxylic Acids under Mild Conditions.

Xu Xiaojuan X Yan Dandan D Zhu Zhangye Z Kang Zihan Z Yao Yingming Y Shen Qi Q Xue Mingqiang M

ACS omega 20190415 4

Herein, we present a facile method for deoxygenative hydroboration of a broad range of carboxylic acids under very mild conditions. The most striking feature of this attractive hydroboration is that this elusive and challenging transformation was realized without catalyst and solvent. The investigation of solvent effect showed that tetrahydrofuran was also suitable for this kind of reaction. Moreover, a successful gram-scale trial may provide a very promising toolkit for carboxylic acid reductio ...[more]

PMID: 31459799

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