Ontology highlight
ABSTRACT:
SUBMITTER: Pearce SHS
PROVIDER: S-EPMC6648194 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Pearce Simon H S SHS Dayan Colin C Wraith David C DC Barrell Kevin K Olive Natalie N Jansson Lotta L Walker-Smith Terrie T Carnegie Christina C Martin Keith F KF Boelaert Kristien K Gilbert Jackie J Higham Claire E CE Muller Ilaria I Murray Robert D RD Perros Petros P Razvi Salman S Vaidya Bijay B Wernig Florian F Kahaly George J GJ
Thyroid : official journal of the American Thyroid Association 20190613 7
<b><i>Background:</i></b> Graves' disease is one of the most common autoimmune conditions, but treatment remains imperfect. This study explores the first-in-human use of antigen-specific immunotherapy with a combination of two thyrotropin receptor (TSHR) peptides (termed ATX-GD-59) in Graves' hyperthyroidism. <b><i>Methods:</i></b> Twelve participants (11 female) with previously untreated mild to moderate Graves' hyperthyroidism were enrolled in a Phase I open label trial to receive 10 doses of ...[more]