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Effect of Biomaterial Electrical Charge on Bone Morphogenetic Protein-2-Induced In Vivo Bone Formation.

ABSTRACT:

Impact statement

Biomaterials can play a dual role in bone regeneration: they enable local sustained delivery of growth factors, such as bone morphogenetic protein-2 (BMP-2), while they provide structural support as scaffold. By better imitating the properties of native bone tissue, scaffolds may be both osteoconductive and osteoinductive. The latter can be achieved by modifying the electrical charge of the surface. The present work uses tunable oligo[(polyethylene glycol) fumarate] hydrogel and demonstrates that negative charge enhances BMP-2-induced bone formation compared with neutral or positive charge. Altogether, this indicates that tissue-specific surface charge modifications of biomaterials hold great promise in the field of tissue regeneration.

SUBMITTER: Olthof MGL

PROVIDER: S-EPMC6648221 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Effect of Biomaterial Electrical Charge on Bone Morphogenetic Protein-2-Induced <i>In Vivo</i> Bone Formation.

Olthof Maurits G L MGL Kempen Diederik H R DHR Liu Xifeng X Dadsetan Mahrokh M Tryfonidou Marianna A MA Yaszemski Michael J MJ Dhert Wouter J A WJA Lu Lichun L

Tissue engineering. Part A 20190614 13-14

<h4>Impact statement</h4>Biomaterials can play a dual role in bone regeneration: they enable local sustained delivery of growth factors, such as bone morphogenetic protein-2 (BMP-2), while they provide structural support as scaffold. By better imitating the properties of native bone tissue, scaffolds may be both osteoconductive and osteoinductive. The latter can be achieved by modifying the electrical charge of the surface. The present work uses tunable oligo[(polyethylene glycol) fumarate] hydr ...[more]

PMID: 30612538

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