Ontology highlight
ABSTRACT:
SUBMITTER: Wu KJ
PROVIDER: S-EPMC6648297 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
ACS omega 20190524 5
The peptidyl-prolyl isomerase Pin1 is correlated with the progression of cervical cancer via regulating numerous oncogenic and tumor suppressor pathways. p65 is a crucial regulator of tumorigenesis that is regulated by Pin1, and p65 signaling suppression can enhance the antitumor efficacy of doxorubicin (DOX). Here, we utilized a structural mimicry approach to synthesize a series of dibenzothiophene analogues and evaluated their ability to inhibit Pin1 activity. Compound <b>1a</b> was identified ...[more]