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Synthesis and Neuroprotective Properties of N-Substituted C-Dialkoxyphosphorylated Nitrones.

ABSTRACT: Herein, we report the synthesis and neuroprotective power of some N-substituted C-(dialkoxy)phosphorylated nitrones 4a-g, by studying their ability to increase the cell viability, as well as their capacity to reduce necrosis and apoptosis. We have identified (Z)-N-tert-butyl-1-(diethoxyphosphoryl)methanimine oxide (4e) as the most potent, nontoxic, and neuroprotective agent, with a high activity against neuronal necrotic cell death, a result that correlates very well with its great capacity for the inhibition of the superoxide production (72%), as well as with the inhibition of lipid peroxidation (62%), and the 5-lipoxygenase activity (45%) at 100 ?M concentrations. Thus, nitrone 4e could be a convenient promising compound for further investigation.

SUBMITTER: Piotrowska DG

PROVIDER: S-EPMC6648307 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Synthesis and Neuroprotective Properties of N-Substituted C-Dialkoxyphosphorylated Nitrones.

Piotrowska Dorota G DG Mediavilla Laura L Cuarental Leticia L Głowacka Iwona E IE Marco-Contelles José J Hadjipavlou-Litina Dimitra D López-Muñoz Francisco F Oset-Gasque María Jesús MJ

ACS omega 20190516 5

Herein, we report the synthesis and neuroprotective power of some N-substituted C-(dialkoxy)phosphorylated nitrones 4a-g, by studying their ability to increase the cell viability, as well as their capacity to reduce necrosis and apoptosis. We have identified (Z)-N-tert-butyl-1-(diethoxyphosphoryl)methanimine oxide (4e) as the most potent, nontoxic, and neuroprotective agent, with a high activity against neuronal necrotic cell death, a result that ...[more]

PMID: 31459948

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