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K2S2O8-Mediated Hydroxyalkylation of Benzothiazoles with Alcohols in Aqueous Solution.


ABSTRACT: The K2S2O8-mediated hydroxyalkylation of 2H-benzothiazoles with aliphatic alcohols in aqueous solution was described. The mild and convenient protocol generated a series of hydroxyalkylated benzothiazoles in moderate to good yields. Besides, benzimidazole and ethers were also compatible in this reaction, leading to corresponding C2 ether-substituted heteroarenes.

SUBMITTER: Xu WX 

PROVIDER: S-EPMC6648524 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-Mediated Hydroxyalkylation of Benzothiazoles with Alcohols in Aqueous Solution.

Xu Wen-Xiu WX   Dai Xiao-Qiang XQ   Weng Jian-Quan JQ  

ACS omega 20190628 6


The K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-mediated hydroxyalkylation of 2<i>H</i>-benzothiazoles with aliphatic alcohols in aqueous solution was described. The mild and convenient protocol generated a series of hydroxyalkylated benzothiazoles in moderate to good yields. Besides, benzimidazole and ethers were also compatible in this reaction, leading to corresponding C2 ether-substituted heteroarenes. ...[more]

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