Novel Ionic Liquid-Functionalized Chitosan [DSIM][AlCl₃] _x ^-@CS: Synthesis, Characterization, and Catalytic Application for Preparation of Substituted Pyrazine Derivatives.

ABSTRACT: Pyrazines are renowned heterocyclic compounds that have played an important role in drug design and are part of many polycyclic compounds of biological and industrial significance. In this article, a novel chitosan-immobilized ionic liquid, [DSIM][AlCl₃] _x ^-@CS, has been synthesized easily at ambient temperature and used for catalyzing the synthesis of a series of biologically relevant pyrazine derivatives. The catalyst is well characterized by various techniques such as Fourier transform infrared spectroscopy, Raman spectroscopy, solid-state ¹³C MAS nuclear magnetic resonance, scanning electron microscopy/energy-dispersive X-ray, elemental mapping, transmission electron microscopy, powder X-ray diffraction, and thermal gravimetric analyses. The advantageous features of the present energy-sustainable methodology include high yield of product (>99%), shorter reaction time periods, and recyclability of the catalyst.

SUBMITTER: Khan MU 

PROVIDER: S-EPMC6648620 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature