Ontology highlight
ABSTRACT:
SUBMITTER: Francis Carballo-Arce A
PROVIDER: S-EPMC6648837 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Francis Carballo-Arce Ana A Raina Vikrant V Liu Suqi S Liu Rui R Jackiewicz Victoria V Carranza David D Arnason John Thor JT Durst Tony T
ACS omega 20190624 6
Synthesis of 50 analogues of the natural insecticide synergists, dillapiol and sesamol, is reported. These were evaluated as potential insecticide synergists based on their inhibition of human CYP3A4. The most potent inhibitors have a relatively large hydrophobic substituent at either position 5 or 6 of these molecules. For example, 5-(benzyloxy)-6-(3-phenylsulfonyl)propyl)benzo[<i>d</i>][1,3]dioxole (<b>18</b>) and the diphenyl acetate of (6,7-dimethoxybenzo[<i>d</i>][1,3]dioxol-5-yl)propan-1-o ...[more]