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Coordination-Driven Self-Assembly of Triazole-Based Apoptosis-Inducible Metallomacrocycles.

ABSTRACT: Ru(II)-metallomacrocycles containing 4-pyridyl-1,2,3-triazole moiety were realized by coordination-driven self-assembly. All new compounds were characterized by electrospray ionisation mass spectrometry, elemental analysis, and 1H and 13C NMR spectroscopic techniques. The molecular structure of metallomacrocycle 8 was determined by single-crystal X-ray crystallography. The anticancer activities of metallomacrocycles 5-8 were evaluated by cytotoxicity, cell cycle analysis, and related protein expression. Metallomacrocycle 7 showed the highest cytotoxicity in HepG2 human hepatocellular carcinoma cells. In addition, apoptotic HepG2 cells were analyzed when metallomacrocycle 7 was treated. Our results suggest that metallomacrocycle 7 induces liver cancer cell death by increasing apoptosis and cell cycle arrest and that it has potential use as an agent for the treatment of human hepatocellular carcinoma.

SUBMITTER: Singh J

PROVIDER: S-EPMC6649141 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Coordination-Driven Self-Assembly of Triazole-Based Apoptosis-Inducible Metallomacrocycles.

Singh Jatinder J Park Dae Won DW Kim Dong Hwan DH Singh Nem N Kang Se Chan SC Chi Ki-Whan KW

ACS omega 20190621 6

Ru(II)-metallomacrocycles containing 4-pyridyl-1,2,3-triazole moiety were realized by coordination-driven self-assembly. All new compounds were characterized by electrospray ionisation mass spectrometry, elemental analysis, and 1H and 13C NMR spectroscopic techniques. The molecular structure of metallomacrocycle 8 was determined by single-crystal X-ray crystallography. The anticancer activities of metallomacrocycles 5-8 were evaluated by cytotoxicity, c ...[more]

PMID: 31460178

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