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Cardiac transplantation in African Americans: a single-center experience.

ABSTRACT: BACKGROUND:In view of limited data on the subject of graft and patient survival differences between African American (AA) and non-AA heart transplant recipients, we reviewed our experience. HYPOTHESIS:There is a higher mortality among AA recipients compared with non-AA recipients after cardiac transplantation. METHODS:The study included all AA patients who have received a heart transplant in our center since 1983. Stepwise Cox regression was used for covariates affecting the survival. The ?(2) test was employed to identify the effects of a mechanical assist device and pretransplant creatinine (Cr) on the outcomes in AA and non-AA patients. Kaplan-Meier curves were used to examine survival. RESULTS:The average survival among AA recipients was 5.4?years, compared with 12 years for the non-AA recipients, with 1-, 5-, and 10-year survival rates of 80%, 55%, and 25%, respectively. This was found to be statistically inferior to the survival probabilities of 92%, 78%, and 58% for the non-AA group (P < 0.005). Based on stepwise Cox regression, the variables such as ethnicity (P < 0.05), pretransplant Cr (P < 0.05), presence of a mechanical assist device (P < 0.005), and United Network for Organ Sharing (UNOS) status at transplant (P < 0.05) independently predicted the outcomes. Kaplan-Meier analysis of pretransplant Cr level and survival showed that the AA group did significantly worse for all Cr classes. CONCLUSIONS:There is a statistically significant difference in outcomes between AA and non-AA patients after cardiac transplantation. African American patients have decreased survival over a period of time. Pretransplant Cr, ethnicity, presence of a mechanical assist device, and UNOS status at transplantation are independent predictors of outcomes.

SUBMITTER: Suryanarayana PG

PROVIDER: S-EPMC6649378 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Cardiac transplantation in African Americans: a single-center experience.

Suryanarayana Prakash Goutham PG Copeland Hannah H Friedman Mark M Copeland Jack G JG

Clinical cardiology 20140401 6

<h4>Background</h4>In view of limited data on the subject of graft and patient survival differences between African American (AA) and non-AA heart transplant recipients, we reviewed our experience.<h4>Hypothesis</h4>There is a higher mortality among AA recipients compared with non-AA recipients after cardiac transplantation.<h4>Methods</h4>The study included all AA patients who have received a heart transplant in our center since 1983. Stepwise Cox regression was used for covariates affecting th ...[more]

PMID: 24692148

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Cardiac transplantation in African Americans: a single-center experience.

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Cardiac transplantation in African Americans: a single-center experience.

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