Ontology highlight
ABSTRACT:
SUBMITTER: Samimi G
PROVIDER: S-EPMC6649708 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Samimi Goli G Trabert Britton B Geczik Ashley M AM Duggan Máire A MA Sherman Mark E ME
JNCI cancer spectrum 20181001 4
Frequent detection of serous tubal intraepithelial carcinoma (STIC) among <i>BRCA1/</i>2 mutation carriers undergoing risk-reducing surgery prompted the hypothesis that many adnexal high-grade serous carcinomas (HGSCs) arise from the fallopian tube, rather than the ovary, as supposed. The changing paradigm has important implications for HGSC prevention. Most data related to the frequency of STIC are derived from case series and estimates vary widely. Therefore, we analyzed population-based data ...[more]