Ontology highlight
ABSTRACT:
SUBMITTER: Onizuka K
PROVIDER: S-EPMC6649768 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Onizuka Kazumitsu K Hazemi Madoka E ME Sato Norihiro N Tsuji Gen-Ichiro GI Ishikawa Shunya S Ozawa Mamiko M Tanno Kousuke K Yamada Ken K Nagatsugi Fumi F
Nucleic acids research 20190701 13
Higher-ordered structure motifs of nucleic acids, such as the G-quadruplex (G-4), mismatched and bulge structures, are significant research targets because these structures are involved in genetic control and diseases. Selective alkylation of these higher-order structures is challenging due to the chemical instability of the alkylating agent and side-reactions with the single- or double-strand DNA and RNA. We now report the reactive OFF-ON type alkylating agents, vinyl-quinazolinone (VQ) precurs ...[more]