Ontology highlight
ABSTRACT:
SUBMITTER: Yoon SY
PROVIDER: S-EPMC6650137 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Yoon Sun-Young SY Dieterich Lothar C LC Tacconi Carlotta C Sesartic Marko M He Yuliang Y Brunner Lorenz L Kwon Ohsang O Detmar Michael M
PloS one 20190723 7
Podoplanin (PDPN) is a glycoprotein that is expressed by various cell types, including keratinocytes, fibroblasts, and lymphatic endothelial cells. We found that PDPN is expressed in the hair follicle (HF) keratinocyte region and HF stem cell area during the late anagen phase but not during the telogen phase in mice. Importantly, keratinocyte-specific PDPN deletion in mice (K5-Cre;PDPNflox/flox) promoted anagen HF growth after depilation-induced HF regeneration as compared to control mice. RNA s ...[more]